Five years prior to The Great Red Dragon, Smith hurt his back helping his cousin move a couch. He was prescribed painkillers by his doctor and quickly found himself addicted to them. During a moment under the influence, he accidentally shot a twelve-year-old girl to death while chasing a gang member. Luckily for him, he was approached by a detective working for The Blake Association, who made his incriminating blood sample disappear and got the investigation shut down. After they saved him from a long jail sentence, they let him join their ranks.
Reede Smith first appears in the Season 5 premiere as an FBI agent sometimes partnered with FBI Agent Gabe Mancini. They were assigned the FBI's investigation of Red John in the fallout over the arrest of Lorelei Martins. Patrick Jane believes the CBI's failure to capture Red John was the result of a mole within the FBI who leaked information to Red John. Agents Smith and Mancini both denied the existence of such a mole but were subsequently dismissed from the Red John case. Instead, he (or agent Mancini) could be also the "good friend in FBI", that RJ nomined in The Crimson Hat.
Smith appears quite taciturn, sarcastic and aggressive. He also seems to have violent instincts repressed.
In Black-Winged Redbird, he is seen in a meeting with Gale Bertram and Thomas McAllister discussing the Red John case and other collaborations. Smith states that Bertram's role in this operation (possibly referring to the involvement of Homeland Security and Robert Kirkland) is to monitor the work of Patrick Jane.
He reveals the existence of a high powered group of law enforcement operatives to Kirkland prior to killing him. It's not revealed though if Red John is a member, or if they are tracking Red John. The group uses the words "Tyger Tyger" to communicate.
In Fire and Brimstone, it is revealed that he doesn't like heights (acrophobia maybe), and that he has a tattoo with three dots, like Gale Bertram, Thomas McAllister and maybe Red John.
In The Great Red Dragon, it is revealed he had an addiction to painkillers. When he was chasing a gangbanger while being high, he killed a twelve year old girl. They had him dead to rights with his blood and witnesses but a detective showed up and claimed they could make it go away. After they were done, the FBI gave Reede a commendation and from that point on he was a member of The Blake Association. It is also revealed that during his tenure as a member of the organization he helped get Rebecca Anderson's killer FBI credentials so he could sneak in and kill her.
- Unnamed twelve year-old girl
- Robert Kirkland
- Out of all Jane's finale seven suspects, he is the only one to survive.